个人简介：
神经内科二级教授/医师，博士生导师。国家杰出青年科学基金获得者、天津市特聘教授。天津医科大学总医院副院长、神经内科癫痫亚专业组长、天津市免疫学研究所副所长、天津市神经病学研究所副所长。中华医学会神经病学分会脑血管病学组委员、中国医师协会神经修复分会常委、中国免疫学会神经免疫分会常委、中国研究型医院学会专委会副主委、天津市免疫学会副理事长。担任Journal of Neuroimmunology副主编。获“科学探索奖（医学科学奖）”、”美国心脏协会（AHA）科学家发展奖”、“天津市津门医学英才”、“天津市优秀青年研究生指导教师”等奖励。
科研成果：
发现了脑疾病患者骨髓造血系统发生髓系增生，可决定神经炎症进展和演变，为通过靶向骨髓造血系统控制自身免疫和神经系统炎性损伤，带来了创新治疗的新理念（Sci Transl Med 2021；Cell 2022）；发现了自然杀伤（NK）细胞可感知脑内的异常神经信号，通过识别MHC-I类分子损伤脑内DCX+细胞，造成持续性神经损伤，为靶向脑内炎症改善脑疾病长期预后提供了新靶点（Nat Neursoci 2016，2021；J Exp Med 2020）；发现脑卒中可通过激活“神经-内分泌-免疫”网络导致卒中后感染并发症和动脉粥样硬化形成加速，从而为防治脑卒中后的感染并发症和卒中再发，提供了新策略（Immunity 2017，2024）。
基于以上发现，刘强教授提出了“靶向骨髓造血系统修饰免疫应答，从而回归免疫稳态，控制神经炎症”这一新理念，主持开展了靶向骨髓免疫，干预脑卒中（MIRACLE: NCT05154734）和神经免疫疾病（BEAT NMO: NCT05369351，BRICS: NCT05792462）等多中心临床研究。研发了靶向骨髓免疫新靶点的全人源化BAFFR抗体（专利号：202311250418.3）和CAR-T细胞（专利号：20231321640.8），并筹备IND申报，有潜力使更多患者获益。这些成果揭示了重大脑疾病的免疫机制，使神经免疫学理论取得了新进展，形成了“临床问题—基础研究—临床转化”的闭环研究范式，为脑疾病的创新治疗提供了新手段。
代表性成果：（†为共同第一作者，*为通信作者）
1. Liu M, Wang D, Qi C, Zou M, Song J, Li L, Xie H, Ren H, Hao H, Yang G, Li Z, Zhang Q*, Zhou J*, Ai D*, Liu Q*. Brain ischemia sustains systemic endothelial Notch1 activity to accelerate atherosclerosis. Immunity. 2024 In press.
2. Zhang W, Sun HS, Wang X, Dumont AS, Liu Q*. Cellular senescence, DNA damage, and neuroinflammation in the aging brain. Trends Neurosci. 2024 May 9:S0166-2236(24)00061-4.
3. Cui Z, Xu H, Wu F, Chen J, Zhu L, Shen Z, Yi X, Yang J, Jia C, Zhang L, Zhou P, Li MJ, Zhu L, Duan S, Yao Z, Yu Y*, Liu Q*, Zhou J*. Maternal circadian rhythm disruption affects neonatal inflammation via metabolic reprograming of myeloid cells. Nat Metab. 2024 Apr 1. doi: 10.1038/s42255-024-01021-y.
4. Shi K, Li H, Chang T, He W, Kong Y, Qi C, Li R, Huang H, Zhu Z, Zheng P, Ruan Z, Zhou J, Shi FD, Liu Q*. Bone marrow hematopoiesis drives multiple sclerosis progression. Cell. 2022;185:2234.
5. Jin WN, Shi K, He W, Sun JH, Van Kaer L, Shi FD, Liu Q*. Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition. Nat Neurosci. 2021;24:61. Editorial highlight: Nat Neurosci. 2021;24:2: “Natural killers of cognition” by Valery Krizhanovsky. Editor’s Choice: Sci Immunol. 2021;6:eabg3186: “Killing the buzz: NK cells in the aged brain” by Rachael A. Clark.
6. Shi SX, Shi KB, Liu Q*. Brain injury instructs bone marrow cellular lineage to reduce neuroinflammation. Sci Transl Med. 2021;13:eabc7029. Sci Transl Med. 2021;13: Cover story: “Nixing neuroinflammation”. Editorial comment: “Promoting neuroimmune interaction after ICH”.
7. Li Z, Li M, Shi S, Yao N, Cheng X, Guo A, Zhu Z, Zhang X, Liu Q*. Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage. J Exp Med. 2020;217:e20200213.
8. Shi SX, Li YJ, Shi K, Wood K, Ducruet AF, Liu Q. IL (Interleukin)-15 Bridges Astrocyte-Microglia Crosstalk and Exacerbates Brain Injury Following Intracerebral Hemorrhage. Stroke. 2020;51:967.
9. Liu Q*, Jin WN, Liu Y, Shi K, Sun H, Zhang F, Zhang C, Gonzales RJ, Sheth KN, La Cava A, Shi FD*. Brain ischemia suppresses immunity in the periphery and brain via different neurogenic innervations. Immunity. 2017; 46:474. Editorial highlight: Immunity. 2017;46:340: “Disarming the killers: brain strikes on NK cells” by Sophie Ugolini.
10. Liu Q*, Sanai N, Jin WN, La Cava A, Van Kaer L, Shi FD*. Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation. Nat Neurosci. 2016;19:243. Editorial highlight: Nat Neurosci. 2016;19:176: “Natural killers in the brain's nursery” by Jonathan Kipnis.