个人简介：
李锐，研究员，博士生导师，福建医科大学免疫治疗研究院副院长，国家自然科学基金优秀青年基金（海外）获得者。博士毕业于加拿大McGill University，后在美国University of Pennsylvania完成博士后研究。曾任University of Pennsylvania神经炎症与实验治疗中心Scientific Director。主要从事神经系统炎性疾病相关的基础以及临床转化研究。
科研成果：
1. 定义新型B细胞亚群BGM-CSF，并揭示其生理及在MS中的病理作用;
2. 揭示调控促炎性和抑炎性B细胞亚群平衡的重要分子、代谢机制，并探索研发新一代治疗MS的B细胞靶向药物
3. B细胞亚群的免疫侧写在MS患者精准化疫苗接种及个体化诊疗中的应用
科研项目：
2023-2025 国家自然科学基金优秀青年基金（海外）
2024-2027 国家自然科学基金区域创新发展联合基金重点项目
2024-2027 国家自然科学基金面上项目
代表性成果：（†为共同第一作者，*为通信作者）
1. Rui Li†,*, Yanting Lei, Ayman Rezk, Diego A. Espinoza, Jing Wang, Huiru Feng, Bo Zhang, Isabella P. Barcelos, Hang Zhang, Jing Yu, Xinrui Huo, Fangyi Zhu, Changxin Yang, Hao Tang, Amy C. Goldstein, Brenda L. Banwell, Hakon Hakonarson, Hongwei Xu, Michael Mingueneau, Bo Sun, Hulun Li, Amit Bar-Or*. Oxidative phosphorylation regulates B cell effector cytokines and promotes inflammation in multiple sclerosis. Science Immunology, 2024, 9(95): eadk0865.
2. Diego A. Espinoza, Carole Le Coz, Emylette Cruz Cabrera, Neil Romberg, Amit Bar-Or*, Rui Li*. Distinct stage-specific transcriptional states of B cells derived from human tonsillar tissue. JCI-insight, 2023, 8(7):e155199.
3. Rui Li†, Hao Tang, Jeremy C. Burns, Brian T. Hopkins, Carole Le Coz, Bo Zhang, Isabella Barcelos, Neil Romberg, Amy C. Goldstein, Brenda L. Banwell, Eline T. Luning Prak, Michael Mingueneau, Amit Bar-Or*. BTK inhibition impacts with B cell - T cell interaction through modulation of B cell metabolism: implications for MS therapies. Acta Neuropathologica. 2022. 143(4): 505-521.
4. Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego Espinoza, Bo Zhang, Roy N Alcalay, Thomas Tropea, Alice Chen-Plotkin, Rui Li*, Amit Bar-Or*. Immune aging in multiple sclerosis is characterized by abnormal CD4 T cell activation and increased frequencies of cytotoxic CD4 T cells with advancing age. EBioMedicine, 2022, 82: 104179.
5. Rui Li†, Thomas F. Tropea, Laurra R. Baratta, Leah Zuroff, Maria E. Diaz-Ortiz, Bo Zhang, Koji Shinoda, Ayman Rezk, Roy N. Alcalay, Alice Chen-Plotkin*, Amit Bar-Or*. Abnormal B-cell and Tfh-cell profiles in patients with Parkinson Disease: a cross-sectional study. Neurology Neuroimmunology & Neuroinflammation, 2021, 9(2): e1125.
6. Sokratis A. Apostolidis, Mihir Kakara, Mark M. Painter, Rishi R. Goel, Divij Mathew, Kerry Lenzi, Ayman Rezk, Kristina R. Patterson, Diego A. Espinoza, Jessy C. Kadri, Daniel M. Markowitz, Clyde E. Markowitz, Ina Mexhitaj, Dina Jacobs, Allison Babb, Michael R. Betts, Eline T. Luning Prak, Daniela Weiskopf, Alba Grifoni, Kendall A Lundgreen, Sigrid Gouma, Alessandro Sette, Paul Bates, Scott E. Hensley, Allison R. Greenplate, E. John Wherry*, Rui Li*, Amit Bar-Or*. Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy. Nature Medicine, 2021, 27(11): 1990-2001.
7. Amit Bar-Or†,* and Rui Li† Cellular Immunology of Multiple Sclerosis: Interactions, Checks and Balances. Lancet Neurology, 2021, 20(6): 470-483.
8. Linlu Tian, Hongxue Meng, Xiao Dong, Xinlei Li, Hulun Li, Lie Zhang, Yue Yang, Ruijie Liu, Chunying Pei, Bo Li, Hongwei Xu*, Rui Li*. IRGM promotes melanoma cell survival through mediating autophagy and is a promising prognostic biomarker for clinical application. Molecular Therapy -Oncolytics, 2021, 20:187-198.
9. Rui Li†, Kristina R. Patterson and Amit Bar-Or*. Reassessing B cell contributions in Multiple Sclerosis. Nature immunology, 2018, 19: 696-707
10. Rui Li†, Ayman Rezk, Yusei Miyazaki, Ellen Hilgenberg, Hanane Touil, Ping Shen, Craig S. Moore, Laure Michel, Faisal Althekair, Sathy Rajasekharan, Jennifer L. Gommerman, Alexandre Prat, Simon Fillatreau, Amit Bar-Or*, Canadian B Cells in MS Team. Proinflammatory GM-CSF–producing B cells in multiple sclerosis and B cell depletion therapy. Science Translational Medicine, 2015, 7(310): 310ra166.