张静
发布人:陈建  发布时间:2022-04-27   浏览次数:552

  

个人简介:

张静女,197811月生,医学博士,博士生导师。曾前往美国国立卫生研究院衰老研究所访问学习。目前兼任中国神经科学学会神经科学研究技术分会委员,中国老年医学学会基础与转化医学分会委员,福建省神经病学分会心身学组委员长期从事老年性痴呆和抑郁症的发病机制和药物防治的研究工作。主要从衰老和遗传风险因素探讨阿尔茨海默病的发病机制;从应激遗传的角度,探讨抑郁症发生发展的分子机制;筛选用于防治阿尔茨海默病和抑郁症的天然植物单体或小分子化合物。

近年来,先后承担了国家自然科学基金和福建省重大研究专项等科研课题近20项,以第一作者或和通讯作者在Neuron、Mol NeurodegenerTransl PsychiatryNeurobiol AgingFASEB J等国际学术期刊上发表SCI论文17篇,其中JCR一区3篇,JCR二区12篇,并获得中华医学科技三等奖1项、福建省科学技术二等奖2项、及福建省医学科技一等奖2项。

科研成果:

人参皂苷改善阿尔茨海默病认知功能的作用及机制研究,福建省科学技术奖,三等奖,排名第三。

发明专利

张静陈晓春,黄炜彬。三醋酸甘油酯在制备预防和治疗抑郁症药物中的用途,ZL201911091155.X

代表性成果:为共同第一作者,*为通信作者)  

1. Fang W, Xiao N, Zeng G, Bi D, Dai X, Mi X, Ye Q, Chen X*, Zhang J*. APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline. Transl Psychiatry2021; 11(1): 507.

2. Huang WB, Hu WM, Cai LL, Zeng GR, Fang WT, Dai XM, Ye QY, Chen XC*, Zhang J*. Acetate supplementation produces antidepressant-like effect via enhanced histone acetylation. J Affect Disord. 2020; 281: 51-60.

3. Fang WT, Zhang J*. Hong LY, Huang WB, Dai XM, Ye QY, Chen XC*. Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation. J Affect Disord2020;260: 302-313.

4. Dai XM, Hong LY, Shen H, Du Q, Ye QY, Chen XC*,Zhang J*. Estradiol-induced senescence of hypothalamic astrocytes contributes to aging-related reproductive function declines in female mice. Aging (Albany NY).2020; 12(7): 6089-6108.

5. Zhang JLin YB, Dai XM, Fang WT, Wu XL, Chen XC*. Metformin treatment improves the spatial memory of the aged mice in an APOE genotype-dependent manner. FASEB J. 2019; 33(6): 7748-7757.

6. Liang B, Zhang L, Barbera G, Fang W, Zhang J, Chen X, Chen R, Li Y*, Lin DT*. Distinct and dynamic ON and OFF Neural ensembles in the Prefrontal Cortex code social exploration. Neuron. 2018; 100(3): 700-714.

7. Zheng KM, Dai XM, Xiao N, Wu XL, Wei Z, Fang WT, Zhu YG,  Zhang J*  and Chen XC*. Curcumin ameliorates memory decline via inhibiting BACE1 expression and β-amyloid pathology in 5×FAD Transgenic Mice. Mol Neurobio2017; 54(3): 1967-1977.

8. Lin LY,  Zhang J, Dai XM, Xiao N, Wu XL, Wei Z, Fang WT, Zhu YG, Chen XC*. Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR miceMol Neurodegener.2016; 11(1): 51.

9. Zhang J*,Yang LM, Lin N, Pan XD, Zhu YG, Chen XC*. Aging-related changes in RP3V kisspeptin neurons predate the reduced activation of GnRH neurons during the early reproductive decline in female mice. Neurobiol aging. 2014,35(3):655-668.

10. Yang L, Zhang J, Zheng K, Shen H, Chen X*. Long-term ginsenoside Rg1 supplementation improves age-related cognitive decline by promoting synaptic plasticity associated protein expression in C57BL/6J mice. J Gerontol A Biol Sci Med Sci. 2014; 69(3): 282-294.